NFL: New England Patriots quarterback will face two opponents in Monday's (AEST) Super Bowl in Minneapolis - the Philadelphia Eagles and Father Time.
If the Patriots win, Brady, 40, will be the oldest quarterback in history to lift the Lombardi Trophy - and New England will claim a record-equalling sixth title.
Brady will be the oldest non-kicker to play in Super Bowl and a sixth title would give Brady more Super Bowl rings than any other player in history.
The veteran quarterback has shown no signs of slowing down.
He threw a league-leading 4577 yards this season, and is the favourite to be named the NFL's season MVP.
"My motivation comes from just trying to be the best I can be for this team,” he said.
"What's happened in the past is great, but it's not going to win us anything this weekend.”
The Eagles powered into the Super Bowl by thrashing the Minnesota Vikings 38-7 and are looking for their first win in the big show.
Philly made finale game after a dazzling display from quarterback Nick Foles, the back-up who was thrust into the starting position after an injury ended Carson Wentz's season in December.
Foles, 29, was only 16 when Brady won his third Super Bowl ring, against the Eagles in 2005.
More than 100 million households in the United States are expected to tune in to the game.
The game will end a tumultuous NFL season rocked by player protests and a feud with President Donald Trump.
Trump triggered a furious backlash across the NFL last September after disparaging mostly African-American players who refused to stand for the national anthem in a protest against social injustices.
Advertisers are expected to steer clear of politically charged TV ads, in contrast to last year, when issues such as immigration and women's rights were tackled.
Pop star Justin Timberlake, who headlines the halftime show, also will aim to avoid controversy, 14 years after the TV audience was scandalised by Janet Jackson's "wardrobe malfunction” in "Nipplegate”.
The game comes one year after Brady inspired New England to the greatest comeback in Super Bowl history, when the Patriots overturned a 28-3 third quarter deficit to beat the Atlanta Falcons 34-28 in overtime.
Yet there are clouds on the horizon for the Patriots.
Two of head coach Bill Belichick's most trusted lieutenants, offensive coordinator Josh McDaniels and defensive counterpart Matt Patricia, are expected to depart at the end of the season to pursue head-coaching opportunities.
And the Boston franchise's campaign has also been jolted by a reported rift - that was denied - between Belichick, Brady and team owner Robert Kraft, sparked by the shock trade of back-up quarterback Jimmy Garoppolo in October.