Senator Lambie has resigned from the Palmer United Party

UPDATE: NEWLY independent Senator Jacqui Lambie has promised to vote against the Abbott government's cuts to welfare payments and higher education after leaving the Palmer United Party on Monday.

After weeks of vitriolic in-fighting, Sen Lambie officially resigned from Clive Palmer's minor party on Monday, declaring she did not have the time or energy for a "political mud-slinging contest".

Sen Lambie said she was open to negotiations with the major parties and the rest of the Senate crossbench on all except three issues.

Those three issues, which she described as non-negotiable on Monday, were reforms to the university sector, the $7 GP co-payment and cuts to welfare payments across the board.

She said she was also a "big supporter" of solar and hydroelectricity in Tasmania, which would be key to any deliberations over changes to the national renewable energy target.

EARLIER: SENATOR Jacqui Lambie has officially left the Palmer United Party, resigning with a short statement to the Senate this morning in Canberra.

Her resignation follows a running political battle between Sen Lambie and PUP leader Clive Palmer over recent weeks.

It began with a break with party policy over Defence force pay decisions by an independent tribunal, before relations broke down last week.

Sen Lambie spent the weekend speaking to her political advisors, friends and family about her decision to leave the minor party.

PUP Senator Jacqui Lambie speaks during Senate question time at Parliament House in Canberra, Tuesday, July 8, 2014.
PUP Senator Jacqui Lambie speaks during Senate question time at Parliament House in Canberra, Tuesday, July 8, 2014. AAP Image - Lukas Coch

The resignation will change the Senate crossbench with wide-ranging implications for the government, which can no longer rely on Mr Palmer's Senate bloc to ensure passage of legislation.

It will further disrupt Senate talks in the future, as Labor and The Greens can similarly not use the PUP, now down to only two Senate votes, in combination to block government legislation.

Sen Lambie said this morning she wished Mr Palmer and the PUP all the best, but that she did not "have the time or the energy to be drawn into a political mud-slinging contest".

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