RESIDENTS in a Coffs Harbour street called 000 in shock after the sound of gunfire rang out during an alarming drive-by shooting that riddled a house with bullets.

Numerous gunshots were fired from a vehicle at an unoccupied home in Prince James Ave and police said it was incredibly lucky no one was home at the time.

"The damage that was done to the premises both externally and internally could have been catastrophic had somebody been home," Coffs Clarence Crime Manager Detective Inspector Darren Jameson said.

The gunshots were fired at the front of the home, penetrating walls and windows facing a verandah and flying through a lounge room.

The owners of the premises have since been interviewed and detectives are working to establish the motive for the drive-by.

"A crime scene was established at the location and we canvassed the area and took statements from a number of people," Det Insp Jameson said.

"There is a vehicle of interest that we are looking for, a white Holden Commodore ute, high-performance style, that was seen leaving the area at high speed with its lights off."

Insp Jameson said ballistic and forensic examinations have since determined what type of firearm may have been used.

"We are aware of the type of calibre and possible firearm that may have been used, but at this stage we are not releasing that information," he said.

"We are very, very concerned about the brazen nature and also the risk that has been posed to the community.

"These cowards that drive around with guns firing bullets out of moving cars need to be caught and brought to justice.

"We have got an investigative team that is on that and we will continue making those inquiries."

Police have appealed for anyone who saw or heard anything suspicious in the area at the time to come forward.

Information will be treated with the strictest of confidence and can be given anonymously to detectives through Crime Stoppers on 1800 333 000.

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